Our Featured Research Page lists cancer prevention, treatment and quality of life studies enrolling people with or at high risk for hereditary cancers. You can do a quick search to filter our featured studies by cancer type, study type or key word, or a more in-depth search through clinicaltrials.gov.
Featured Studies Results
The DETECT Study: Detecting Endometrial Cancer in Tampons
Clinicaltrials.gov identifier:
NCT03538665
Prevention
Early detection of endometrial cancer in women over 45 years of age who are undergoing hysterectomy surgery at the University of Alabama
PreCharge: Digital Program for People Affected by Hereditary Cancer
Quality of Life
Study to help people affected by hereditary cancer and who have not been diagnosed with cancer improve their mental and emotional well-being
FORCE Survey for People at Increased Risk for Colorectal, Pancreatic or Prostate Cancer
Surveys, Registries, Interviews
Survey for people at high risk for Colorectal, Pancreatic or Prostate Cancer
PATROL Study: Prostate Cancer Screening for People AT Genetic Risk FOr Aggressive Disease
Clinicaltrials.gov identifier:
NCT04472338
Prevention
Screening study for people with a mutation linked to prostate cancer risk
Pancreatic Cancer Screening Study (CAPS5)
Clinicaltrials.gov identifier:
NCT02000089
Prevention
Screening study for people at high risk for pancreatic cancer
Testing A Combination Of Vaccines For Cancer Prevention In Lynch Syndrome
Clinicaltrials.gov identifier:
NCT05419011
Prevention
Testing A Combination Of Vaccines For Cancer Prevention In Lynch Syndrome
Cancer Prevention Vaccine (Nous-209) for People with Lynch Syndrome
Clinicaltrials.gov identifier:
NCT05078866
Prevention
Prevention study for people with Lynch syndrome
Registry to Discover New Treatments and Developmental Processes of Colorectal and Endometrial Cancer in Patients with Hereditary Cancer
Clinicaltrials.gov identifier:
NCT06096688
Surveys, Registries, Interviews
Study to collect and save data, cancer samples, and cancer family health histories from people who screen for colorectal endometrial cancer
The Phoenix Trial: Cemiplimab for Patients with Localized dMMR Colon Cancer
Clinicaltrials.gov identifier:
NCT05961709
Treatment
This study will examine how well Cemiplimab works for patients with localized colon cancer who have dMMR
Roadmap to Parenthood: A Study about Fertility and Family-Building After Cancer
Clinicaltrials.gov identifier:
NCT06050135
Surveys, Registries, Interviews
Roadmap to Parenthood is a remote, survey-based study. Eligible participants must be aged 18-45, assigned female at birth, and history of a cancer diagnosis
Screening Study for Men at High Genetic Risk for Prostate Cancer
Clinicaltrials.gov identifier:
NCT03805919
Prevention
Prostate screening with MRI for men with Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM) or a BRCA1, BRCA2, HOXB13, ATM, NBN, TP53, BRIP1, CHEK2, PALB2, RAD51C, RAD51D, or other mutation
Studying a Combination of Three Drugs to Treat Previously Untreated Metastatic Colorectal Cancer with Certain Tumor Markers
Clinicaltrials.gov identifier:
NCT05217446
Treatment
Study for metastatic colorectal cancer that has not yet been treated
Using ctDNA for Earlier Detection and Treatment of Recurrence or Spread after Treatment for Stage 3 Colon Cancer
Clinicaltrials.gov identifier:
NCT03803553
Treatment
Monitoring and treatment study for people who completed treatment for stage 3 colon cancer
Exploring How People of Caribbean Descent Share Information About Their Genetic Mutations with Family Members
Surveys, Registries, Interviews
Survey and interview for people of Caribbean descent who tested positive for a genetic mutation linked to cancer.
Treatment of HER2-positive Colorectal Cancer as First Line Treatment in the Metastatic Setting
Clinicaltrials.gov identifier:
NCT05253651
Treatment
People with HER2-positive colorectal cancer who have not yet received treatment in the metastatic setting
Study of Colorectal Cancer and Genetics in Hispanic and Latino People (ENLACE Study)
Treatment
Hispanic and Latino people diagnosed with colorectal cancer
Pancreatic Cancer Early Detection for People at High Risk
Clinicaltrials.gov identifier:
NCT04970056
Prevention
Registry and biobank for high risk people undergoing pancreatic cancer screening
Early Detection of Colorectal Cancer for People with Lynch Syndrome
Clinicaltrials.gov identifier:
NCT05410977
Prevention
People with Lynch Syndrome at risk for colon cancer
Screening in Men at High Risk of Developing Prostate Cancer
Clinicaltrials.gov identifier:
NCT05608694
Prevention
Screening using MRI for men at risk of developing prostate cancer
My Best GI Eating Study
Clinicaltrials.gov identifier:
NCT05396846
Prevention
Diet and weight loss study for people who are overweight and at increased risk of colorectal cancer
Registry to Promote Health Equity for People of African Ancestry with Breast or Prostate Cancer
Clinicaltrials.gov identifier:
NCT05754658
Surveys, Registries, Interviews
This is a registry for people of African ancestry who have breast or prostate cancer
Survey about Motivations and Barriers to Talking with Family Members about Inherited Cancer Risk
Surveys, Registries, Interviews
Survey for people with an inherited gene mutation
Studying the Use of Naproxen and Aspirin for Cancer Prevention in People with Lynch Syndrome
Clinicaltrials.gov identifier:
NCT05411718
Prevention
Prevention study for people with Lynch syndrome
Testing Immunotherapy Treatments for Recurrent Endometrial Cancer
Clinicaltrials.gov identifier:
NCT05112601
Treatment
Treatment study for people with endometrial cancer that has returned
Tools To Be Fit: Tools to Improve Nutrition and Physical Activity for Cancer Survivors
Clinicaltrials.gov identifier:
NCT05056077
Quality of Life
Bladder, breast, colon, endometrial, kidney (renal cell carcinoma), ovarian, prostate, or rectal cancer
Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)
Clinicaltrials.gov identifier:
NCT05129605
Prevention
People at high risk for prostate cancer due to an inherited mutation
Blood Markers of Early Pancreas Cancer
Clinicaltrials.gov identifier:
NCT03568630
Prevention
Observational study for people with family history of pancreas cancer or an inherited mutation linked to pancreatic cancer risk.
Upright MRI for Prostate Cancer Screening
Clinicaltrials.gov identifier:
NCT03474913
Prevention
Screening for prostate cancer using upright MRI
Helping People With a Genetic Mutation in BRCA1, BRCA2 or Lynch Syndrome Talk to Their Family Members About Their Risk for Cancer and Find the Best Way to Get Family Members Tested
Clinicaltrials.gov identifier:
NCT05677048
Prevention
People with a genetic mutation in BRCA1, BRCA2 or Lynch syndrome who have relatives who have not been tested
Inherited Cancer Registry (ICARE): Contribute to Research While Staying Informed
Clinicaltrials.gov identifier:
NCT03231891
Surveys, Registries, Interviews
People with an inherited mutation or cancer in the family
Nivolumab and Relatlimab in Advanced MSI-H Cancers Resistant to Prior PD-L1 Inhibitor
Clinicaltrials.gov identifier:
NCT03607890
Treatment
Solid tumors that are MSI-High and resistant to prior immunotherapy
Chemotherapy, Bevacizumab, and/or Atezolizumab for dMMR / MSI-H Metastatic Colorectal Cancer (COMMIT Study)
Clinicaltrials.gov identifier:
NCT02997228
Treatment
Validating a Blood Test for Early Ovarian Cancer Detection in High-risk Women and Families
Prevention
Screening study for women with a BRCA1, BRCA2, BRIP1, PALB2, RAD51C, RAD51D, PMS2, MLH1, MSH2, MSH6, or EPCAM mutation
Nivolumab, Nivolumab Plus Ipilimumab, or Chemotherapy for Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (CheckMate 8HW)
Clinicaltrials.gov identifier:
NCT04008030
Treatment
People with metastatic colorectal cancer that is MSI-High
Pancreatic Cancer Screening Study for High Risk People
Clinicaltrials.gov identifier:
NCT03250078
Prevention
If you would like a more in-depth search, visit our In-Depth Search Tool that searches for studies in FORCE’s database and in clinicaltrials.gov
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