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CDK4: Cancer Risk
People with an inherited mutation in the CDK4 gene have an increased risk for melanoma. Learn more how
CDK4 mutations affect cancer risk.
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Cancer Risk Associated with Inherited CDK4 Mutations
If you have tested positive for an inherited CDK4 mutation, we recommend that you speak with a genetics expert who can look at your personal and family history of cancer and can help you choose the best plan for managing your cancer risk.
- People who have a CDK4 mutation have a very high lifetime risk of developing melanoma, which may be as high as 80%. The lifetime risk for melanoma in someone without a mutation is about 2.5 percent.
- People with a CDK4 mutation may have an increased risk of developing pancreatic cancer. More research is needed to confirm this link.
Related Resources
Organizations that provide information and resources for people diagnosed with melanoma include:
- AIM at Melanoma is a nonprofit organization that has online support and in-person support groups by region and a lookup tool for finding a melanoma expert by location.
Organizations that provide support and resources for people diagnosed with pancreatic cancer include:
- PanCAN is a nonprofit organization for people diagnosed with pancreatic cancer.
- Let's Win PC is a nonprofit organization that enables doctors, scientists, and patients to share fast-breaking information on potentially life-saving pancreatic cancer treatments and clinical trials.
Last updated June 29, 2024