STK11 Gene Mutations (Peutz-Jeghers Syndrome)
Information for People with Inherited Mutations ()
What is an mutation?
Inherited mutations cause a condition known as Peutz-Jeghers syndrome.
What are the cancer risks for people with an mutation?
People with an in have a very high lifetime risk for different types of cancers, including:
- breast cancer
- colorectal cancer
- endometrial cancer
- lung cancer
- pancreatic cancer
- stomach cancer
- small intestinal cancer
- other cancers
What can people with an mutation do?
There are expert guidelines with recommendations for screening and prevention of these cancers.
People with mutations can develop medical conditions beyond cancer, beginning at an early age. There may be family planning considerations for people with an inherited mutation.
Each of these topics is outlined in more detail in the sections highlighted below.
More Information on Mutations
Cancer Risks
Cancer risk estimates are updated based on the latest research. Read about the lifetime risk for different cancers in people with inherited mutations.
Risk Management Options
Read about the latest expert guidelines for cancer screening and prevention for people with a mutation. Learn about research studies enrolling high-risk patients.
Cancer Treatment Options
People with a mutation who have been diagnosed with cancer may qualify for specific treatments or clinical trials.
Other Considerations
People with mutations can develop medical conditions beyond cancer, beginning at an early age. Learn about other important considerations for people with inherited mutations.
Participate in Research
The studies below are enrolling people with mutations. To search for more studies, visit our Search and Enroll Tool.
Pancreatic Cancer Screening Study for High Risk People
Clinicaltrials.gov identifier:
NCT03250078
Pancreatic Cancer Early Detection for People at High Risk
Clinicaltrials.gov identifier:
NCT04970056