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Search Results: Prevention, Detection & Risk + Breast Cancer (9 results)

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Denosumab for Breast Cancer Risk Reduction in Women With an Inherited BRCA1 Mutation (The Breast Cancer Prevention Study)

Prevention
Prevention study enrolling women ages 25-55 with a BRCA1 mutation

Denosumab for Breast Cancer Risk Reduction in Women With an Inherited BRCA1 Mutation (The Breast Cancer Prevention Study)

This is a study to test the effectiveness of a drug (denosumab) on preventing the development of breast cancer in women with an inherited BRCA1 mutation.

Denosumab is a drug that is currently used to treat bone loss in order to reduce the risk of broken bones in healthy people, and is also used to reduce new bone growths in cancer patients whose cancer has spread to their bones. Research has shown that denosumab may also reduce the risk of developing breast cancer in women with an inherited BRCA1 mutation.

Clinicaltrials.gov identifier: NCT04711109
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Testing a Vaccine for Preventing or Treating Triple-Negative Breast Cancer

Prevention
Prevention study for people with a BRCA1, BRCA2 or PALB2 inherited mutation who are planning to undergo risk-reducing mastectomy

Testing a Vaccine for Preventing or Treating Triple-Negative Breast Cancer

Researchers are studying the affects of this breast cancer vaccine on the immune system in two groups of people:

  • People with an inherited mutation in BRCA1, BRCA2, or PALB2 who are planning to undergo a risk-reducing mastectomy.
  • For people diagnosed with stage 2 or stage 3 triple-negative breast cancer at high risk for recurrence.
Clinicaltrials.gov identifier: NCT04674306
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WISDOM Study: Women Informed to Screen Depending on Measures of Risk

Prevention
Study to determine if breast cancer screening can be made better by personalizing each woman’s mammogram schedule

The WISDOM Study: Women Informed to Screen Depending on Measures of Risk

The goal of the Wisdom Study is to determine if breast cancer screening can be made better by personalizing each woman’s mammogram schedule, compared to the current one-size-fits-all, annual approach. The Wisdom Study is designed to end the confusion about when to start and how often to have a mammogram. 

Clinicaltrials.gov identifier: NCT02620852
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Testing  a Vaccine for Cancer Prevention in People with a BRCA1 or BRCA2 Mutation

Prevention
People with a BRCA1 or BRCA2 mutation

Testing a Vaccine for Cancer Prevention in People with a BRCA1 or BRCA2 Mutation

This study will look at a new vaccine known as INO-5401 used alone or combined with a second vaccine called INO-9012. The study will test if the vaccine is safe (without large side effects) and test a new way of giving vaccines. It will also test whether the vaccine activates the immune system. A goal of this research is to reduce cancer risk in people with a BRCA1 or BRCA2 mutation. Additional studies will be needed to learn if this vaccine approach lowers cancer risk in mutation carriers. 

Clinicaltrials.gov identifier: NCT04367675
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Restoring Sensation after DIEP Flap Reconstruction

Prevention
Study for people undergoing DIEP flap reconstruction

Restoring Sensation after DIEP Flap Reconstruction

The goal of this study is to look at how well a nerve graft works for improving sensation to the reconstructed breast after mastectomy in people undergoing DIEP flap reconstruction (deep inferior epigastric perforator flap). 

 

Clinicaltrials.gov identifier: NCT04533373
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Helping Latinas Understand Their Risk for Breast Cancer and Get Breast Cancer Care

Prevention
Latinas with a high risk of breast cancer

Helping Latinas Understand Their Risk for Breast Cancer and Get Breast Cancer Care

This study will teach Latinas with a high risk of breast cancer about how diet, exercise, ethnicity, genetics and screening and prevention guidelines may impact their likelihood for developing breast cancer. The study will test ways of teaching participants about breast cancer and risk factors, comparing the current standard of care to new personal educational sessions. Bilingual and bicultural staff are available for the phone study to make the study open to both English and Spanish speakers.

Clinicaltrials.gov identifier: NCT05483283
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Helping People With a Genetic Mutation in BRCA1, BRCA2 or Lynch Syndrome Talk to Their Family Members About Their Risk for Cancer and Find the Best Way to Get Family Members Tested

Prevention
People with a genetic mutation in BRCA1, BRCA2 or Lynch syndrome who have relatives who have not been tested

IGNITE-TX - Identifying Individuals for Genetic Testing for Familial Cancer

The IGNITE-TX study is all about helping people with a genetic mutation in BRCA1, BRCA2 or Lynch syndrome talk to their family members about their risk for cancer and find the best way to get family members tested.

Clinicaltrials.gov identifier: NCT05677048
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Blood Tests to Measure Ovarian Reserves in Women with a BRCA Mutation or Women Treated for Early-Stage Breast Cancer

Prevention
Study for premenopausal women with early-stage breast cancer and high-risk women with BRCA mutations and no evidence of breast or ovarian cancer

Serum Biomarkers to Characterize the Effects of Therapy on Ovarian Reserve in Premenopausal Women With Early-stage Breast Cancer or BRCA Mutations

The purpose of this study is to see how cancer treatment affects the ovaries, such as the impact on conceiving a child or the early onset of menopause. Comparatively, the study will also look at high-risk women with BRCA1/2 mutations (and no evidence of breast or ovarian cancer).

The study will check blood levels of hormones that the ovaries produce and will use questionnaires to gather information about participant menstrual cycles, health, and pregnancies. 

Clinicaltrials.gov identifier: NCT00823654
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Study for People with Unexpected Genetic Results

Prevention
This study is recruiting people who received unexpected genetic test results about their cancer risk after having genetic testing done for some other reason

Genomic Services Research Program Study for People with Unexpected Genetic Results

A new study is recruiting people who received unexpected genetic test results about their cancer risk after having genetic testing done for some other reason.

This is a study of people with "secondary results” from genetic testing. Secondary results are unexpected. They are not related to the reason the person had the genetic test but are shared because they may be very important to the person’s health. Most secondary results have to do with high risks for health problems that can be treated or prevented. Many of these results are related to cancer risk. If you think you have received a secondary result, you may be eligible to join this study.

Clinicaltrials.gov identifier: NCT02595957
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Additional Results on Clinicaltrials.gov Prevention, Detection & Risk + Breast Cancer
49 results
Clinical Trial Official Title
NCT05721976 With Love, Grandma ("Con Cariño, Abuelita") Pilot Study
NCT05408260 A Study to Compare the Effectiveness of Two Types of Ultrasound Technologies in Women Who Have Had Breast Cancer
NCT05665660 Developing and Evaluating Culturally Relevant Interventions to Improve Breast Cancer Screening
NCT06643767 Evaluation of the Bexa Breast Examination
NCT06082882 Salud en Mis Manos - Breast and Cervical Cancer Prevention and Early Detection - Expansion 2
NCT04904757 Contrast-enhanced Spectral Mammography (CESM) Breast Cancer Screening
NCT04722692 Delayed Sentinel Lymph Node Biopsy in Ductal Cancer in Situ
NCT04331535 The Genomic Medicine at VA Study
NCT06305312 Community Services Navigation to Advance Health Equity in Breast Cancer Screening
NCT04877912 Accurate, Rapid and Inexpensive MRI Protocol for Breast Cancer Screening
NCT01035112 Magnetic Resonance Imaging of Breast Cancer
NCT04854304 Abbreviate or FAST Breast MRI for Supplemental Breast Cancer Screening for Black Women at Average Risk and Dense Breasts
NCT06485089 Effects of Tirzepatide on Blood, Imaging and Breast Tissue Biomarkers
NCT05810025 FHIR-Enhanced RealRisks to Improve Accuracy of Breast Cancer Risk Assessments
NCT05968157 MIRAI-MRI: Comparing Screening MRI for Patients at High Risk for Breast Cancer Identified by Mirai and Tyrer-Cuzick
NCT04961996 A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)
NCT04496739 Making Informed Choices on Incorporating Chemoprevention Into Care (MiCHOICE)
NCT06547034 VisR for Noninvasively Interrogating Stromal Collagen Organization as a Breast Cancer Biomarker: Evaluation of Compression in Control Subjects
NCT06011434 Testing Conversation Aid in Practice
NCT05056818 Comparison of Synthetic Mammography Versus Full-Field Digital Mammography in Image Interpretation and Performance Metrics
NCT00291096 Protocol for Women at Increased Risk of Developing Breast Cancer
NCT05036096 Cone Beam Breast CT for Breast Cancer Screening
NCT04348123 Interventional Program Educates, Identifies + Overcomes Barriers to Complete Screening Mammography
NCT04379414 YES Study - Newly Diagnosed/Metastatic Intervention
NCT05838417 Promoting Informed Choice for Breast Cancer Screening: A Longitudinal Study
NCT05841355 Empowering Latinas to Obtain Guideline Concordant Screenings
NCT06112795 Exploring Cultural Acceptability of Community Breast Cancer Risk Assessment Among Hispanic Women in Maricopa County
NCT06105749 Biennial CEM in Women with a Personal History of Breast Cancer
NCT05975736 Searching for Masses and Calcifications at the Same Time in Breast Cancer Screening
NCT04152499 Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies
NCT06340503 Evaluating a Physical Activity Index for Assessment and Counseling for Breast and Colon Cancer Survivors
NCT04651452 Writing Interventions in Breast Cancer Patients Taking Aromatase Inhibitors
NCT05625659 Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts
NCT03729115 A Multi-Modality Surveillance Program for Women at High Risk for Breast Cancer
NCT04967352 Predicting Chronic Pain Following Breast Surgery
NCT05667532 The C-MERIT Screening Cohort: Contrast-enhanced Mammography for Breast Cancer Screening and Risk Assessment in Women With Dense Breasts
NCT05960188 Project 1: Self-Triage by 2D Full-field Digital Mammography or Synthetic Images
NCT05483283 Empowering Vulnerable and Resilient Latinas to Obtain Breast Cancer Care
NCT06336928 A Validation Study to Determine Concordance of Liquid Biopsy and Breast Cancer Diagnosis
NCT02928978 Ruxolitinib for Premalignant Breast Disease
NCT06604078 Breast Cancer AI Imaging Study
NCT06043661 Early Detection of Breast Cancer
NCT03623945 Autoantibodies in Breast Cancer Detection
NCT05298605 Faith in Action! A Church-Based Navigation Model to Increase Breast Cancer Screening in Korean Women
NCT05754658 African Cancer Genome: GMD
NCT04711109 Studying the Effect of Denosumab on Preventing Breast Cancer in Women With a BRCA1 Germline Mutation
NCT04030507 Screening Magnetic Resonance Imaging of the Brain in Patients With Breast Cancer
NCT05694559 Connecting Black Families in Houston, Texas to Hereditary Cancer Genetic Counseling, Genetic Testing, and Cascade Testing by Using a Simple Genetic Risk Screening Tool and Telegenetics
NCT02694809 The PROMISE Study: Duavee in Women With DCIS

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