FORCE's eXamining the Relevance of Articles for You (XRAY) program looks behind the headlines of cancer news to help you understand what the research means for you.
XRAY is a reliable source of hereditary cancer research-related news and information.
Learn more about the XRAY program
Breast Cancer
Relevance: Medium-High
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Strength of Science: Medium-High
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Research Timeline: Human Research
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Study : Yearly breast MRI screening improves outcomes for women with inherited BRCA mutations
Relevance: Medium-High
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Strength of Science: Medium-High
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Research Timeline: Human Research
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Most relevant for: People with a BRCA1 or BRCA2 mutation who are considering breast MRI screening
An international research study of yearly breast MRI screening among women with BRCA1 and BRCA2 gene mutations found that BRCA1 carriers who had MRI screenings were less likely to die of breast cancer than those who did not. Additional studies with more BRCA2 mutation carriers are needed to determine if yearly breast MRIs reduce deaths from breast cancer in this group. (Posted 6/24/24)
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Relevance: Medium-High
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Strength of Science: High
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Research Timeline: Post Approval
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Update : Targeted therapy for early-stage HER2-positive breast cancer continues to show benefit
Relevance: Medium-High
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Strength of Science: High
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Research Timeline: Post Approval
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Most relevant for: People with early-stage HER2-postive breast cancer
People with early-stage HER2-positive breast cancer benefit from targeted therapy. This update includes new data on survival and the length of time without cancer returning. (Posted 6/20/24)
Read More![](https://www.facingourrisk.org/cdn-cgi/image/width=400,height=400,fit=contain,format=webp/uploads/assets/xray/6674644b8142f.jpg)
Relevance: Medium
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Personal Story : Living a full life with Li-Fraumeni syndrome
Relevance: Medium
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Most relevant for: People with Li-Fraumeni syndrome
This XRAY review is about a five-time cancer survivor who has an inherited mutation in the TP53 gene. People with inherited mutations in TP53 have Li-Fraumeni syndrome, which is linked to a very high lifetime risk for many types of cancer. Here we share his inspiring story and provide more information on Li-Fraumeni syndrome. (Posted 4/16/24)
Read More![](https://www.facingourrisk.org/cdn-cgi/image/width=400,height=400,fit=contain,format=webp/uploads/assets/xray/661e8f7b09c18.jpg)
Topic : Progress in the treatment of triple-negative breast cancer
Most relevant for: People with triple-negative breast cancer
During the December 2023 San Antonio Breast Cancer Symposium, Dr. Melinda Telli presented a summary of research that has led to better treatments for triple-negative breast cancer (TNBC). These treatments now include drugs called targeted therapies and immunotherapies for both early and late stages of TNBC. (Posted 3/19/24)
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Relevance: High
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Strength of Science: High
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Research Timeline: Post Approval
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Study : Genetic testing among people with cancer can find mutations that may affect treatment and prevention
Relevance: High
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Strength of Science: High
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Research Timeline: Post Approval
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Most relevant for: People diagnosed with cancer who have not yet had genetic testing
Despite national guidelines recommending genetic testing, less than 10 percent of eligible patients had genetic testing within two years after their cancer diagnosis. Among those who had testing, 10-30 percent had an inherited mutation that could affect their medical care. (Posted 3/15/2024)
Read More![](https://www.facingourrisk.org/cdn-cgi/image/width=400,height=400,fit=contain,format=webp/uploads/assets/xray/65f48ecc60823.jpg)
Relevance: Medium
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Update : News from the FDA– new breast cancer treatment, thermography warning and implant screening updates
Relevance: Medium
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Most relevant for: People with HR-positive and HER2-negative metastatic breast cancer. People with silicone breast implants. People considering thermography screening
This XRAY review is a summary of FDA breast cancer updates from July to December 2023. This includes a new drug approval and two consumer updates. (Posted 2/21/24)
Read More![](https://www.facingourrisk.org/cdn-cgi/image/width=400,height=400,fit=contain,format=webp/uploads/assets/xray/65d6aa71286b2.jpg)
Relevance: Medium-High
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Strength of Science: Medium-High
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Research Timeline: Post Approval
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Study : Estrogen without progesterone for hormone replacement may lower breast cancer risk
Relevance: Medium-High
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Strength of Science: Medium-High
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Research Timeline: Post Approval
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Most relevant for: Postmenopausal people on hormone replacement therapy
Women with average breast cancer risk who took estrogen without progesterone after menopause had lower rates of breast cancer than those who did not take any hormone replacement. This finding comes from studies looking at the safety of the use of estrogen alone as hormone replacement therapy. (Posted 2/13/24)
Este artículo está disponible en español.
Read More![](https://www.facingourrisk.org/cdn-cgi/image/width=400,height=400,fit=contain,format=webp/uploads/assets/xray/65cbace42936b.jpg)
Update : New drug combination for the second treatment of some HR-positive advanced breast cancers
Most relevant for: People with hormone receptor (HR)-positive or HER2-negative breast cancer that has spread outside the breast tissue.
The FDA approved Truqap plus Faslodex for the treatment of metastatic hormone receptor-positive (HR-positive), HER2-negative breast cancer that returned or worsened after treatment with hormone therapy. The approval is for treating cancers in people whose tumors had a mutation in one of three genes. For people with one of these mutations, Truqap improved the time until their cancer came back or got worse. (Posted 2/9/24)
Este artículo está disponible en español.
Read More![](https://www.facingourrisk.org/cdn-cgi/image/width=400,height=400,fit=contain,format=webp/uploads/assets/xray/65c677a11075a.jpg)
Update : A breast cancer vaccine for people with an inherited BRCA1, BRCA2 or PALB2 mutation
Most relevant for: People at increased risk for breast cancer undergoing prophylactic bilateral mastectomy due to an inherited mutation in BRCA1, BRCA2 or PALB2. People with TNBC who still have breast cancer after chemotherapy.
A breast cancer vaccine is showing promise in early clinical trials. Initially, the vaccine was tested in people with triple-negative breast cancer (TNBC) who were at high risk for recurrence. Now the vaccine is being tested to lower breast cancer risk among people with an inherited mutation in BRCA1, BRCA2 or PALB2. It is also being tested in people with triple-negative breast cancer who are at high risk for recurrence and are taking the immunotherapy drug Keytruda (pembrolizumab) after completing chemotherapy. (Posted 1/31/24)
Este artículo está disponible en español.
Read More![](https://www.facingourrisk.org/cdn-cgi/image/width=400,height=400,fit=contain,format=webp/uploads/assets/xray/65bac28bd2a72.jpg)
Relevance: Medium
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Article : Breast cancer risk for transgender women with inherited mutations
Relevance: Medium
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Most relevant for: Transgender women with inherited mutations who are considering or have had gender affirming care
There has been little research on breast cancer risk for transgender women who are at high risk for breast cancer due to an inherited mutation. This review summarizes what we know. (Posted 11/29/23)
Este artículo está disponible en español.
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