FORCE's eXamining the Relevance of Articles for You (XRAY) program looks behind the headlines of cancer news to help you understand what the research means for you.
XRAY is a reliable source of hereditary cancer research-related news and information.
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Update : New drug combination for early treatment of some metastatic prostate cancer
Most relevant for: People with metastatic castration resistant prostate cancer with a mutation in BRCA1 or BRCA2
The FDA approved Lynparza (olaparib) for use earlier in treatment of metastatic castration-resistant prostate cancer (mCRPC) when added to abiraterone and prednisone for people with a BRCA mutation found through genetic or tumor testing. Lynparza combined with hormone therapy may now be used as a first-line or later treatment. (Posted 9/11/23)
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Relevance: Medium-Low
Quality of Writing: Medium
Research Timeline: Animal Studies
Article : Promising drug for cancer treatment begins clinical trials
Relevance: Medium-Low
Quality of Writing: Medium
Research Timeline: Animal Studies
Most relevant for: People with solid tumors.
Researchers at City of Hope are testing a new type of cancer treatment drug. When tested in animals and cells taken from human cancers, this new drug prevented the growth of many types of cancer. Initial clinical trials in people have just started. (Posted 9/7/23)
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Relevance: Medium-High
Strength of Science: Medium-High
Research Timeline: Human Research
Study : Personalized vaccines may help pancreatic cancer treatment
Relevance: Medium-High
Strength of Science: Medium-High
Research Timeline: Human Research
Most relevant for: People with pancreatic cancer who have tumors that can be removed by surgery
Pancreatic cancer is usually diagnosed at a late stage when patients have few treatment options. Early study results showed that a pancreatic cancer vaccine delayed the return of cancer for nearly half of the participants. (Posted 8/29/23)
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Topic : Colorectal cancer is on the rise in young adults: What Millennials and Gen Zs need to know
Most relevant for: Young adults
The rate of colorectal cancer among young adults in the US has been increasing since the 1990s. Scientists are trying to figure out why. (Posted 8/15/23)
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Topic : Sex and intimacy after breast cancer
Most relevant for: People with breast cancer or metastatic breast cancer in sexual or intimate relationships and their partners
A breast cancer diagnosis and treatment can affect relationships with romantic partners. This review highlights two studies that looked at how people with breast cancer and their partners are affected, how they cope, how best to communicate with each other and how to talk with healthcare providers about concerns related to cancer and sexuality. (Posted 8/8/23)
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Relevance: Medium-High
Strength of Science: High
Research Timeline: Post Approval
Study : New treatment option for advanced or recurrent endometrial cancer
Relevance: Medium-High
Strength of Science: High
Research Timeline: Post Approval
Most relevant for: People with advanced or recurrent endometrial cancer
If you have advanced or recurrent endometrial cancer, there is a new treatment called Jemperli (dostarlimab) that could be an option for you. This study looked at how well Jemperli worked compared to standard treatment. Based on these results, the Food and Drug Administration (FDA) approved the combination of Jemperli and chemotherapy for certain types of advanced endometrial cancer. (Posted 8/4/23)
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Topic : Reducing ovarian cancer risk without removing the ovaries
Most relevant for: People who are not at high risk of ovarian cancer who are having pelvic surgery
A leading ovarian cancer organization has recommended that all women who have pelvic surgery should also consider removing their fallopian tubes to reduce their risk of ovarian cancer. (Posted 7/18/23)
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Relevance: Medium-High
Strength of Science: High
Research Timeline: Post Approval
Study : Progestin birth control may slightly increase breast cancer risk
Relevance: Medium-High
Strength of Science: High
Research Timeline: Post Approval
Most relevant for: People who are using or have recently used birth control containing only the hormone progestin
Different types of birth control carry different cancer risks. Birth control using the hormone progestin slightly increases the risk of breast cancer during use and for a few years after use. (Posted 7/10/23)
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Study : Breast cancer disparities among the LGBTQ+ community
Most relevant for: People belonging to the LGBTQ+ community
This study looked at differences in breast cancer treatment outcomes among people from the LGBTQ+ community. (Posted 6/28/23)
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Relevance: Medium-High
Guideline : What is breast density and why does it matter?
Relevance: Medium-High
Most relevant for: People who have mammograms
New FDA guidelines for mammograms will go into effect by September 2024. Current FDA guidance requires hospitals and breast centers to give people information about their breast density with their mammogram results. By September 2024, mammogram providers will need to relay to patients who have dense breast that they should discuss the need for additional imaging. This article provides an overview of what breast density means and why it matters. (Posted 6/8/23)
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