IGNITE-TX - Identifying Individuals for Genetic Testing for Familial Cancer
https://www.facingourrisk.org/research-clinical-trials/study/266/helping-people-with-a-genetic-mutation-in-brca1-brca2-or-lynch-syndrome-talk-to-their-family-members-about-their-risk-for-cancer-and-find-the-best-way-to-get-family-members-tested
Clinicaltrials.gov identifier:
NCT05677048 (https://clinicaltrials.gov/show/NCT05677048)
Prevention
People with a genetic mutation in BRCA1, BRCA2 or Lynch syndrome who have relatives who have not been tested
Study Contact Information:
J. Alejandro Rauh-Hain, PI
Heidy Bosch Study Coordinator
Study specific contact information: [email protected], Phone: 713 792 9155
About the Study
The IGNITE-TX study explores ways to increase genetic testing for family members of those diagnosed with Lynch Syndrome or a BRCA1 or BRCA2 genetic mutation. This is also known as cascade genetic testing.
What the Study Involves
If an individual is eligible for the study, they will be granted access to the IGNITE-TX website. The website contains information about their genetic mutation and how to share information with family members. Participants and their family members will be placed at random into four groups:
Group 1) Standard of care, which is receiving a letter with information on their specific hereditary cancer syndrome that they can share with their relatives
Group 2) free genetic counseling and testing
Group 3) the IGNITE-TX intervention which gives family members access to the website and education modules as well as access to a study navigator
Group 4) The IGNITE-TX intervention and free genetic counseling and testing.
All participants (including family members enrolled in the study) will be asked to complete a baseline survey and then follow-up surveys at 6 and 12 months. Participants will receive a $10 dollar gift card after the completion of each survey.
Study Locations
We are targeting enrollment in the states of Texas, Alabama, and California. The institutions and individuals we are collaborating with are listed below, but enrollment is not limited to a single site in the state. However, we will include patients in other states if they enroll through the website.
Alabama
Birmingham
University of Alabama
Contact: Charles Leath at [email protected]
California
Los Angeles
University of California Los Angeles Jonsson Comprehensive Cancer Center
Contact: Beth Karlan at [email protected]
Texas
Houston
MD Anderson Cancer Center
Contact: J. Alejandro Rauh-Hain at [email protected]
Lead Researchers/Study PIs and Affiliation
Study PI: J. Alejandro Rauh-Hain, University of Texas MD Anderson Cancer Center
This Study is Open To:
- 18 years of age or older
- You or your family member has a positive genetic test result for the BRCA1, BRCA2 mutation or Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM mutation)
- You have an email address and/or a U.S. cell phone number
- You speak English or Spanish
This Study is Not Open To:
- You do not have any relatives
- You do not have one of the genetic conditions listed above or only have been told you have a variant of uncertain significance
About FORCE
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.