Atorvastatin ± Aspirin for Colorectal Cancer Prevention for People with Lynch Syndrome
https://www.facingourrisk.org/research-clinical-trials/study/144/atorvastatin-aspirin-for-colorectal-cancer-prevention-for-people-with-lynch-syndrome
Clinicaltrials.gov identifier:
NCT04379999 (https://clinicaltrials.gov/show/NCT04379999)
Study Contact Information:
Contact: Yana Chertock, MA by phone: 215-214-3216 or by email
About the Study
This study is no longer recruiting people.
This study will look at how well atorvastatin (a common cholesterol lowering agent) works with or without aspirin in preventing colorectal cancer in people with Lynch syndrome. Atorvastatin may lower the risk of developing cancers in the colon and rectum. Aspirin may reduce the risk of colon polyps and colon cancers. Giving atorvastatin and aspirin may work better at reducing the risk of colorectal cancer (CRC) in high-risk individuals with Lynch syndrome.
What the Study Entails
Participants in this study will be divided into two groups based on their prior history of polyps/cancer. Both the researchers and the participants will know about the treatment being administered to each group.
At entry to the study, all participants will undergo a colonoscopy and biopsy of normal tissue.
- Group 1: Patients with no history of colorectal cancer and no colorectal polyps within 5 years will receive Atorvastatin (LIPITOR) 20 mg tablet daily for 6 weeks.
- Group 2: Patients with a history of colorectal cancer and/or history of colorectal polyps within 5 years will receive Atorvastatin (LIPITOR) 20 mg tablet and Aspirin 325 mg tablet daily for 6 weeks
After 6 weeks of taking prescribed drugs, study participants will undergo a second colonoscopy and biopsy of normal tissue.
Study Site
Philadelphia, Pennsylvania
Fox Chase Cancer Center
Contact: Yana Chertock, MA by phone: 215-214-3216 or by email
Contact: Michael Hall, MD, MS by phone: 215-728-2791 or by email
This Study is Open To:
This study is no longer recruiting people.
This Study is Not Open To:
This study is no longer recruiting people.
About FORCE
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.