Featured Studies Results
Understanding Risk Factors for Stomach Cancer in People with Inherited Mutations
https://www.facingourrisk.org/research-clinical-trials/study/332/understanding-risk-factors-for-stomach-cancer-in-people-with-inherited-mutations
Surveys, Registries, Interviews
Online survey on stomach cancer risk for people with an inherited mutation in genes that are linked to an increased risk of certain cancers
Pfizer Clinical Trials for Metastatic Prostate Cancer are Now Enrolling
https://www.facingourrisk.org/research-clinical-trials/study/321/pfizer-clinical-trials-for-metastatic-prostate-cancer-are-now-enrolling
Treatment
Men aged 18 years or older with metastatic prostate cancer
What Happens to Tissue or Blood Samples you Donate as Part of Research?
https://www.facingourrisk.org/research-clinical-trials/study/327/what-happens-to-tissue-or-blood-samples-you-donate-as-part-of-research
Surveys, Registries, Interviews
Survey to share your views on a new method to track research specimens
The American Cancer Society’s “VOICES of Black Women” Observational Study
https://www.facingourrisk.org/research-clinical-trials/study/336/the-american-cancer-societys-voices-of-black-women-observational-study
Surveys, Registries, Interviews
VOICES of Black Women is a study led by the American Cancer Society to better understand cancer and other health conditions among Black women
Sexual Health and Rehabilitation Online (SHAREonline): An Educational Intervention for Young Women after Cancer
https://www.facingourrisk.org/research-clinical-trials/study/323/sexual-health-and-rehabilitation-online-shareonline-an-educational-intervention-for-young-women-after-cancer
Clinicaltrials.gov identifier:
NCT06458049 (https://clinicaltrials.gov/show/NCT06458049)
Quality of Life
An online study comparing two educational interventions for female cancer survivors experiencing sexual health changes
Understanding the Emotional and Social Experiences of Individuals Diagnosed with Ovarian Cancer
https://www.facingourrisk.org/research-clinical-trials/study/335/understanding-the-emotional-and-social-experiences-of-individuals-living-with-ovarian-cancer
Surveys, Registries, Interviews
Survey for people diagnosed with ovarian cancer
Pancreatic Cancer Screening Study (CAPS5)
https://www.facingourrisk.org/research-clinical-trials/study/222/pancreatic-cancer-screening-studycaps5
Clinicaltrials.gov identifier:
NCT02000089 (https://clinicaltrials.gov/show/NCT02000089)
Prevention
Screening study for people at high risk for pancreatic cancer
PATROL Study: Prostate Cancer Screening for People AT Genetic Risk FOr Aggressive Disease
https://www.facingourrisk.org/research-clinical-trials/study/291/patrol-study-prostate-cancer-screening-for-people-at-genetic-risk-for-aggressive-disease
Clinicaltrials.gov identifier:
NCT04472338 (https://clinicaltrials.gov/show/NCT04472338)
Prevention
Screening study for people with a mutation linked to prostate cancer risk
Understanding the Cancer Journey: A Survey of Patient Experiences and Emotional Impact
https://www.facingourrisk.org/research-clinical-trials/study/319/understanding-the-cancer-journey-a-survey-of-patient-experiences-and-emotional-impact
Surveys, Registries, Interviews
Online survey for people diagnosed with breast, colorectal, gastric or prostate cancer within the past twenty years
The DETECT Study: Detecting Endometrial Cancer in Tampons
https://www.facingourrisk.org/research-clinical-trials/study/306/the-detect-study-detecting-endometrial-cancer-in-tampons
Clinicaltrials.gov identifier:
NCT03538665 (https://clinicaltrials.gov/show/NCT03538665)
Prevention
Early detection of endometrial cancer in women over 45 years of age who are undergoing hysterectomy surgery at the University of Alabama
Lynch Syndrome Vaccine Study
https://www.facingourrisk.org/research-clinical-trials/study/273/testing-a-combination-of-vaccines-for-cancer-prevention-in-lynch-syndrome
Clinicaltrials.gov identifier:
NCT05419011 (https://clinicaltrials.gov/show/NCT05419011)
Prevention
Testing a combination of vaccines for cancer prevention in Lynch syndrome
Effectiveness of Lymph Node Mapping to Reduce the Risk of Swelling in the Legs in Patients with Stage I Endometrial Cancer
https://www.facingourrisk.org/research-clinical-trials/study/310/effectiveness-of-lymph-node-mapping-to-reduce-the-risk-of-swelling-in-the-legs-in-patients-with-stage-i-endometrial-cancer
Clinicaltrials.gov identifier:
NCT05646316 (https://clinicaltrials.gov/show/NCT05646316)
Treatment
People with stage I endometrial cancer who are having a hysterectomy
Roadmap to Parenthood: A Study about Fertility and Family-Building After Cancer
https://www.facingourrisk.org/research-clinical-trials/study/302/roadmap-to-parenthood-a-study-about-fertility-and-family-building-after-cancer
Clinicaltrials.gov identifier:
NCT06050135 (https://clinicaltrials.gov/show/NCT06050135)
Surveys, Registries, Interviews
A survey for people aged 18-45, assigned female at birth, and history of a cancer diagnosis
Registry to Discover New Treatments and Developmental Processes of Colorectal and Endometrial Cancer in Patients with Hereditary Cancer
https://www.facingourrisk.org/research-clinical-trials/study/301/registry-to-discover-new-treatments-and-developmental-processes-of-colorectal-and-endometrial-cancer-in-patients-with-hereditary-cancer
Clinicaltrials.gov identifier:
NCT06096688 (https://clinicaltrials.gov/show/NCT06096688)
Surveys, Registries, Interviews
Study to collect and save data, cancer samples, and cancer family health histories from people who screen for colorectal endometrial cancer
Study of a New Treatment Called ONM-501 Alone and in Combination with Immunotherapy for Triple Negative Breast Cancer, Advanced Solid Tumors and Lymphomas
https://www.facingourrisk.org/research-clinical-trials/study/311/study-of-a-new-treatment-called-onm-501-alone-and-in-combination-with-cemiplimab-in-people-with-triple-negative-breast-cancer-advanced-solid-tumors-and-lymphomas
Clinicaltrials.gov identifier:
NCT06022029 (https://clinicaltrials.gov/show/NCT06022029)
Treatment
Treatment study for people with triple negative breast cancer, advanced solid tumors or lymphomas
The Phoenix Trial: Cemiplimab for Patients with Localized dMMR Colon Cancer
https://www.facingourrisk.org/research-clinical-trials/study/299/the-phoenix-trial-cemiplimab-for-patients-with-localized-dmmr-colon-cancer
Clinicaltrials.gov identifier:
NCT05961709 (https://clinicaltrials.gov/show/NCT05961709)
Treatment
This study will examine how well Cemiplimab works for patients with localized colon cancer who have dMMR
Screening Study for Men at High Genetic Risk for Prostate Cancer
https://www.facingourrisk.org/research-clinical-trials/study/72/men-at-high-genetic-risk-for-prostate-cancer
Clinicaltrials.gov identifier:
NCT03805919 (https://clinicaltrials.gov/show/NCT03805919)
Prevention
Prostate screening with MRI for men with Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM) or a BRCA1, BRCA2, HOXB13, ATM, NBN, TP53, BRIP1, CHEK2, PALB2, RAD51C, RAD51D, or other mutation
Using ctDNA Blood Test for Earlier Detection and Treatment of Recurrence or Spread after Treatment for Stage 3 Colon Cancer
https://www.facingourrisk.org/research-clinical-trials/study/283/using-ctdna-for-earlier-detection-and-treatment-of-recurrence-or-spread-after-treatment-for-stage-3-colon-cancer
Clinicaltrials.gov identifier:
NCT03803553 (https://clinicaltrials.gov/show/NCT03803553)
Treatment
Monitoring and treatment study for people who completed treatment for stage 3 colon cancer
Comparing a Combination of Drugs for Treatment of HER2-positive Colorectal Cancer as First Line Treatment in the Metastatic Setting
https://www.facingourrisk.org/research-clinical-trials/study/274/treatment-of-her2-positive-colorectal-cancer-as-first-line-treatment-in-the-metastatic-setting
Clinicaltrials.gov identifier:
NCT05253651 (https://clinicaltrials.gov/show/NCT05253651)
Treatment
People with HER2-positive colorectal cancer who have not yet received treatment in the metastatic setting
Study of Colorectal Cancer and Genetics in Hispanic and Latino People (ENLACE Study)
https://www.facingourrisk.org/research-clinical-trials/study/276/study-of-colorectal-cancer-and-genetics-in-hispanic-and-latino-people-enlace-study
Treatment
Hispanic and Latino people diagnosed with colorectal cancer
Pancreatic Cancer Early Detection for People at High Risk
https://www.facingourrisk.org/research-clinical-trials/study/227/pancreatic-cancer-early-detection-for-people-at-high-risk
Clinicaltrials.gov identifier:
NCT04970056 (https://clinicaltrials.gov/show/NCT04970056)
Prevention
Registry and biobank for high risk people undergoing pancreatic cancer screening
Collecting Blood and Stool Samples to Detect Colorectal Cancer or Precancerous Polyps in Lynch Syndrome Patients, CORAL Study
https://www.facingourrisk.org/research-clinical-trials/study/256/early-detection-of-colorectal-cancer-for-people-with-lynch-syndrome
Clinicaltrials.gov identifier:
NCT05410977 (https://clinicaltrials.gov/show/NCT05410977)
Prevention
People with Lynch Syndrome at risk for colon cancer
MRI Screening in Men at High Risk of Developing Prostate Cancer
https://www.facingourrisk.org/research-clinical-trials/study/260/screening-in-men-at-high-risk-of-developing-prostate-cancer
Clinicaltrials.gov identifier:
NCT05608694 (https://clinicaltrials.gov/show/NCT05608694)
Prevention
Screening using MRI for men at risk of developing prostate cancer
My Best GI Eating Study
https://www.facingourrisk.org/research-clinical-trials/study/258/my-best-gi-eating-study
Clinicaltrials.gov identifier:
NCT05396846 (https://clinicaltrials.gov/show/NCT05396846)
Prevention
Diet and weight loss study for people who are overweight and at increased risk of colorectal cancer
A Study Comparing Two Anti-inflammatory Medications Naproxen or Aspirin for Cancer Prevention in Lynch Syndrome
https://www.facingourrisk.org/research-clinical-trials/study/281/studying-the-use-of-naproxen-and-aspirin-for-cancer-prevention-in-people-with-lynch-syndrome
Clinicaltrials.gov identifier:
NCT05411718 (https://clinicaltrials.gov/show/NCT05411718)
Prevention
Prevention study for people with Lynch syndrome
Tools To Be Fit: Tools to Improve Nutrition and Physical Activity for Cancer Survivors
https://www.facingourrisk.org/research-clinical-trials/study/171/tools-to-be-fit-tools-to-improve-nutrition-and-physical-activity-for-colorectal-cancer-survivors
Clinicaltrials.gov identifier:
NCT05056077 (https://clinicaltrials.gov/show/NCT05056077)
Quality of Life
Bladder, breast, colon, endometrial, kidney (renal cell carcinoma), ovarian, prostate, or rectal cancer
Prostate Cancer Genetic Risk Evaluation and Screening Study (PROGRESS)
https://www.facingourrisk.org/research-clinical-trials/study/180/prostate-cancer-genetic-risk-evaluation-and-screening-study-progress
Clinicaltrials.gov identifier:
NCT05129605 (https://clinicaltrials.gov/show/NCT05129605)
Prevention
People at high risk for prostate cancer due to an inherited mutation
Blood Markers of Early Pancreas Cancer
https://www.facingourrisk.org/research-clinical-trials/study/141/blood-markers-of-early-pancreas-cancer
Clinicaltrials.gov identifier:
NCT03568630 (https://clinicaltrials.gov/show/NCT03568630)
Prevention
Observational study for people with family history of pancreas cancer or an inherited mutation linked to pancreatic cancer risk
Upright MRI for Prostate Cancer Screening
https://www.facingourrisk.org/research-clinical-trials/study/259/upright-mri-for-prostate-cancer-screening
Clinicaltrials.gov identifier:
NCT03474913 (https://clinicaltrials.gov/show/NCT03474913)
Prevention
Screening for prostate cancer using upright MRI
Inherited Cancer Registry (ICARE): Contribute to Research While Staying Informed
https://www.facingourrisk.org/research-clinical-trials/study/195/inherited-cancer-registry-icare-contribute-to-research-while-staying-informed
Clinicaltrials.gov identifier:
NCT03231891 (https://clinicaltrials.gov/show/NCT03231891)
Surveys, Registries, Interviews
People with an inherited mutation or cancer in the family
Nivolumab and Relatlimab in Advanced Mismatch Repair Deficient (dMMR/MSI-High) Cancers Resistant to Prior PD-L1 Inhibitor
https://www.facingourrisk.org/research-clinical-trials/study/151/nivolumab-and-relatlimab-in-advanced-msi-h-cancers-resistant-to-prior-pd-l1-inhibitor
Clinicaltrials.gov identifier:
NCT03607890 (https://clinicaltrials.gov/show/NCT03607890)
Treatment
Solid tumors that are MSI-High and resistant to prior immunotherapy
Validating a Blood Test for Early Ovarian Cancer Detection in High-risk Women and Families: MicroRNA Detection Study (MiDE)
https://www.facingourrisk.org/research-clinical-trials/study/138/validating-a-blood-test-for-early-ovarian-cancer-detection-in-high-risk-women-and-families
Prevention
Screening study for women with a BRCA1, BRCA2, BRIP1, PALB2, RAD51C, RAD51D, PMS2, MLH1, MSH2, MSH6, or EPCAM mutation
A Pancreatic Cancer Screening Study for High Risk Individuals
https://www.facingourrisk.org/research-clinical-trials/study/95/pancreatic-cancer-screening-study-for-high-risk-people
Clinicaltrials.gov identifier:
NCT03250078 (https://clinicaltrials.gov/show/NCT03250078)
Prevention
Screening study to detect pancreatic cancer and precancer in people with either a strong family history of pancreatic cancer, or an inherited mutation associated with pancreatic cancer risk
Energetics and Lifestyle in Inherited Syndromes (ELLIE’s Study)
https://www.facingourrisk.org/research-clinical-trials/study/84/ellies-project
Quality of Life
A survey to gain a better understanding of the baseline lifestyle factors related to nutrition and physical activity in people with a hereditary cancer gene mutation
About FORCE
FORCE is a national nonprofit organization, established in 1999. Our mission is to improve the lives of individuals and families affected by adult hereditary cancers.